1. PRODUCT OVERVIEW
MOTS-c is a mitochondria-derived peptide encoded by mitochondrial DNA, consisting of 16 amino acids. It is translated from an open reading frame within the mitochondrial 12S rRNA and is considered a signaling molecule involved in communication between mitochondria and the cell nucleus. In scientific research, MOTS-c is studied for its role in cellular adaptation, metabolic regulation, and stress-response pathways. It is particularly relevant in investigations of mitochondrial-nuclear signaling and cellular energy homeostasis.
2. STORAGE & HANDLING PROTOCOL
Long-term Storage: Maintain the lyophilized powder at -20°C (-4°F). Ensure the vial remains sealed and protected from light.
Post-Reconstitution: Reconstitute with sterile diluent. Store the resulting solution at 2–8°C (36–46°F).
Stability: For maximum experimental integrity, utilize the reconstituted product within 30 days. Avoid vigorous mechanical agitation.
3. POTENTIAL RESEARCH APPLICATIONS
This compound is intended for the following areas of laboratory study:
Mitochondrial Signaling: Investigating mitochondrial-nuclear communication and its role in cellular adaptation processes.
Metabolic Homeostasis: Evaluating the mechanisms of energy balance and systemic metabolic regulation.
AMPK Pathway Analysis: Studying metabolic flexibility and the activation of intracellular signaling pathways, specifically AMPK.
Cellular Stress Response: Researching biological triggers involved in stress-response pathways and maintaining cellular stability.
4. REGULATORY DISCLAIMER
NOTICE: This product is supplied strictly FOR LABORATORY RESEARCH and development purposes. It is NOT FOR HUMAN CONSUMPTION, therapeutic, or diagnostic use. This material must be handled by qualified scientific professionals in a controlled environment.
5. REFERENCES
- The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance
https://pubmed.ncbi.nlm.nih.gov/25738459 - MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis
https://www.nature.com/articles/s41467-020-20790-0 - MOTS-c: A promising mitochondrial-derived peptide for metabolic regulation
https://pubmed.ncbi.nlm.nih.gov/36761202 - MOTS-c, the most recent mitochondrial-derived peptide in metabolic regulation
https://pubmed.ncbi.nlm.nih.gov/36233287 - Mitochondria-derived peptide MOTS-c: effects and mechanisms in metabolic regulation
https://pmc.ncbi.nlm.nih.gov/articles/PMC9854231 - Mitochondrial-encoded peptide MOTS-c, diabetes, and aging
https://pubmed.ncbi.nlm.nih.gov/36824008 - MOTS-c improves intrinsic muscle mitochondrial bioenergetics via AMPK-dependent mechanisms
https://pubmed.ncbi.nlm.nih.gov/41520850
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