1. PRODUCT SUMMARY
LL-37 is the sole identified human cathelicidin-derived antimicrobial peptide (hCAP18) and a primary effector of the innate immune system. In experimental workflows, LL-37 is utilized as a potent tool to examine host-defense mechanisms, barrier functions, and tissue repair. Its biological versatility makes it a focus for studying direct pathogen-killing activities, the disruption of complex microbial biofilms, and the modulation of inflammatory signaling pathways.
2. STORAGE & HANDLING PROTOCOL
Lyophilized State: Store at 2–8°C (36–46°F), kept desiccated and shielded from light. For extended stability, storage at -20°C (-4°F) is recommended.
Reconstitution: Typically handled with sterile diluents such as bacteriostatic water.
Stability: Avoid repeated freeze-thaw cycles once reconstituted. Ensure sterile handling to prevent peptide degradation.
3. PRIMARY RESEARCH AREAS
Antimicrobial Mechanisms: Investigating membrane-disruption pathways against a broad spectrum of bacteria, fungi, and viruses.
Biofilm Eradication: In-vitro analysis of LL-37’s efficacy in destabilizing established bacterial biofilms.
Tissue Engineering & Repair: Focused studies on keratinocyte migration, epithelial barrier restoration, and wound-healing kinetics.
Immunological Assays: Exploring chemotactic activity and the regulation of pro- and anti-inflammatory cytokine signaling.
4. REGULATORY DISCLAIMER
NOTICE: This product is supplied strictly for laboratory research and development. It is STRICTLY NOT FOR HUMAN OR VETERINARY USE, nor is it intended for any clinical, therapeutic, or diagnostic applications. Handling must be restricted to qualified scientific professionals in a controlled environment.
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