1. PRODUCT OVERVIEW
Tesamorelin is a stabilized synthetic peptide analog of Growth Hormone-Releasing Hormone (GHRH 1–44). Featuring a trans-3-hexenoic acid modification at the N-terminus, it exhibits enhanced stability and potent binding affinity for GHRH receptors. It is a primary tool in endocrine research for investigating growth hormone (GH) synthesis, somatotropic axis regulation, and receptor-ligand interaction kinetics.
2. STORAGE & HANDLING
Long-term Storage: Keep lyophilized powder at -20°C (-4°F). Protect from light exposure and moisture.
Post-Reconstitution: Store the liquid solution at 2–8°C (36–46°F). For optimal experimental integrity, use within 30 days of reconstitution.
Handling: Avoid vigorous vortexing; gentle swirling is recommended during dissolution.
3. POTENTIAL RESEARCH APPLICATIONS
GHRHR Pharmacology: Assaying ligand potency, binding affinity, and receptor-activation thresholds.
Signaling Pathways: Measuring second-messenger responses, specifically the adenylate cyclase/cAMP-linked cascades.
Somatotropic Mapping: Detailed investigation of the GH/IGF-1 axis feedback loops in controlled in-vitro and in-vivo models.
Metabolic Research: Exploratory workflows focused on neuroendocrine signaling and energy balance biomarkers.
4. REGULATORY DISCLAIMER
NOTICE: This material is supplied strictly for laboratory research and development. It is NOT FOR HUMAN CONSUMPTION, nor for any therapeutic, clinical, or diagnostic applications. Handling must be performed by qualified scientific personnel only.
5. REFERENCES
- Metabolic Effects of a Growth Hormone–Releasing Factor in Patients with HIV
https://pubmed.ncbi.nlm.nih.gov/20101189 - Metabolic Effects of a Growth Hormone–Releasing Factor in HIV-Infected Patients with Abdominal Fat Accumulation
https://www.nejm.org/doi/full/10.1056/NEJMoa072375 - Long-term safety and effects of tesamorelin, a growth hormone–releasing hormone analogue
https://pubmed.ncbi.nlm.nih.gov/18690162 - Effect of Tesamorelin on Visceral Fat and Liver Fat in HIV-Infected Patients: A Randomized Clinical Trial
https://jamanetwork.com/journals/jama/fullarticle/1889139 - Tesamorelin improves fat quality independent of changes in fat quantity
https://pmc.ncbi.nlm.nih.gov/articles/PMC8243807 - Predictors of Treatment Response to Tesamorelin
https://pmc.ncbi.nlm.nih.gov/articles/PMC4601733 - Efficacy and safety of tesamorelin in people with HIV
https://pubmed.ncbi.nlm.nih.gov/38905488
Reviews
There are no reviews yet.