1. PRODUCT SUMMARY
5-Amino-1MQ is a synthetic small-molecule inhibitor of Nicotinamide N-methyltransferase (NNMT), an enzyme involved in NAD+ metabolism. This compound is widely used in scientific research to investigate methylation pathways and their impact on cellular metabolism. By inhibiting NNMT, 5-Amino-1MQ indirectly affects the availability of methyl donors and pathways associated with the biosynthesis of S-adenosylmethionine (SAM), which may influence cellular regulation, inflammation, and metabolic processes.
2. STORAGE & HANDLING PROTOCOL
Long-term Storage: Maintain the lyophilized powder at -20°C (-4°F). Ensure the vial remains sealed and protected from light.
Post-Reconstitution: Reconstitute with sterile diluent. Store the resulting solution at 2–8°C (36–46°F).
Stability: For maximum experimental integrity, utilize the reconstituted product within 30 days. Avoid vigorous mechanical agitation.
3. POTENTIAL RESEARCH APPLICATIONS
NNMT Pathway Analysis: Investigating the inhibition of nicotinamide N-methyltransferase and its role in cellular methylation processes.
Adipogenesis & Metabolic Flux: Studying the mechanisms of fat cell development and the regulation of cellular energy homeostasis.
Inflammatory Signaling: Mapping the compound’s influence on pathways responsible for systemic and adipose-specific inflammatory responses.
Preclinical Metabolic Modeling: Evaluating the effects of NNMT modulation in research models related to obesity and cancer-linked metabolism.
4. REGULATORY DISCLAIMER
NOTICE: This product is supplied strictly FOR LABORATORY RESEARCH and development purposes. It is NOT FOR HUMAN CONSUMPTION, therapeutic, or diagnostic use. This material must be handled by qualified scientific professionals in a controlled environment.
5. REFERENCES
- Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase (NNMT)
https://pmc.ncbi.nlm.nih.gov/articles/PMC5826726/ - Roles of Nicotinamide N-Methyltransferase in Obesity and Metabolic Disease
https://pmc.ncbi.nlm.nih.gov/articles/PMC8337113/ - Reduced calorie diet combined with inhibition of nicotinamide N-methyltransferase improves metabolic profile in mice
https://pubmed.ncbi.nlm.nih.gov/35013352/ - Nicotinamide N-methyltransferase inhibition mimics and boosts exercise-mediated improvements in muscle function in aged mice
https://www.nature.com/articles/s41598-024-66034-9 - Development and validation of LC-MS/MS assay for 5-amino-1-methylquinolinium in biological samples
https://pubmed.ncbi.nlm.nih.gov/34304009/ - Nicotinamide N-methyltransferase: a metabolic regulator and emerging therapeutic target
https://pmc.ncbi.nlm.nih.gov/articles/PMC11196770/
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