1. PRODUCT OVERVIEW
Semax (ACTH(4-10) analog) is a synthetic heptapeptide and a modified analog of the adrenocorticotropic hormone fragment Adrenocorticotropic hormone (ACTH(4-10)). It is designed to enhance stability and resistance to enzymatic degradation while retaining biological activity associated with the parent fragment. In scientific research, Semax is used to investigate neuroregulation, stress-response mechanisms, and adaptive processes of the central nervous system. It is commonly applied in experimental models to study neurochemical pathways associated with cognitive function and neuronal activity.
2. STORAGE & HANDLING PROTOCOL
Long-term Storage: Maintain the lyophilized powder at -20°C (-4°F). Ensure the vial remains sealed and protected from light.
Post-Reconstitution: Reconstitute with sterile diluent. Store the resulting solution at 2–8°C (36–46°F).
Stability: For maximum experimental integrity, utilize the reconstituted product within 30 days. Avoid vigorous mechanical agitation.
3. POTENTIAL RESEARCH APPLICATIONS
Neurochemical Pharmacology: Assaying peptide interactions with neurotransmitter systems and evaluating activation thresholds within the CNS.
Cognitive Signaling Pathways: Measuring mechanisms involved in learning, memory formation, and cellular responses to external stimuli.
Adaptive Response Mapping: Detailed investigation of neurochemical cascades and feedback loops in controlled models of stress and adaptation.
Neuronal Gene Research: Exploratory workflows focused on the regulation of gene expression and mRNA biomarkers of intercellular communication.
4. REGULATORY DISCLAIMER
NOTICE: This product is supplied strictly FOR LABORATORY RESEARCH and development purposes. It is NOT FOR HUMAN CONSUMPTION, therapeutic, or diagnostic use. This material must be handled by qualified scientific professionals in a controlled environment.
5. REFERENCES
- Semax, an analogue of adrenocorticotropin (4-10), binds specifically and increases levels of brain-derived neurotrophic factor protein in rat basal forebrain
https://pubmed.ncbi.nlm.nih.gov/16635254/ - Semax, an analogue of adrenocorticotropin (4-10) with cognitive effects
https://pubmed.ncbi.nlm.nih.gov/16996037/ - Semax, an ACTH(4-10) analogue with nootropic properties: effects on monoaminergic systems
https://pubmed.ncbi.nlm.nih.gov/16362768/ - Degradation of ACTH/MSH(4-10) and its synthetic analog semax by serum enzymes
https://pubmed.ncbi.nlm.nih.gov/8392718/ - Semax, synthetic ACTH(4-10) analogue, attenuates neuronal damage and modulates signaling pathways
https://pubmed.ncbi.nlm.nih.gov/33418449/ - The peptide Semax affects the expression of genes related to immune and vascular processes in brain ischemia
https://pmc.ncbi.nlm.nih.gov/articles/PMC3987924/ - Semax, an ACTH(4-10) analogue with high affinity for copper(II) ion and protective ability against metal-induced cytotoxicity
https://pubmed.ncbi.nlm.nih.gov/25310602/ - The effect of peptide Semax on intracellular calcium signaling in neurons
https://pubmed.ncbi.nlm.nih.gov/41171324/
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