1. PRODUCT SUMMARY
IGF-1 LR3 is a synthetic analog of Insulin-like Growth Factor 1 with an extended amino acid sequence. The modification includes a substitution at position 3 (Arg instead of Glu) and the addition of a 13-amino-acid N-terminal extension, which reduces binding affinity to IGF-binding proteins (IGFBPs) and increases receptor availability. IGF-1 LR3 is used in scientific research to investigate cellular processes such as proliferation, differentiation, and metabolic regulation, particularly through activation of IGF-1 receptor signaling pathways.
2. STORAGE PROTOCOL
Lyophilized State: Store long-term at -20°C (-4°F). Ensure the vial remains hermetically sealed and shielded from UV exposure.
Reconstituted Solution: Once reconstituted with a sterile diluent, the product must be kept refrigerated at 2–8°C (36–46°F).
Usage Window: For optimal experimental integrity, utilize the reconstituted solution within 30 days. Avoid repeated freeze-thaw cycles or high-speed vortexing.
3. RESEARCH APPLICATIONS
IGF1R Signaling Pathways: Investigating receptor-mediated mechanisms and their influence on cellular growth and proliferation.
Cellular Development & Differentiation: Studying the processes of cell maturation and the regulation of tissue-specific differentiation.
Intracellular Metabolic Mapping: Evaluating the activation of key signaling pathways, including PI3K/AKT, in metabolic regulation.
Binding Protein Interactions: Researching the structural interactions between the peptide and IGF-binding proteins (IGFBPs) in experimental models.
4. REGULATORY DISCLAIMER
NOTICE: This product is supplied strictly for laboratory research and development. It is STRICTLY NOT FOR HUMAN CONSUMPTION, nor is it intended for any clinical, therapeutic, medical, or diagnostic procedures. Use must be restricted to qualified scientific professionals in a controlled environment. This product is not designed to diagnose, treat, or prevent any medical condition.
5. REFERENCES
- Insulin-like Growth Factor-I (IGF-I) and Long R3 IGF-I in early embryonic development
https://pubmed.ncbi.nlm.nih.gov/11181549 - Effects of insulin and insulin-like growth factor-I and LR3 IGF-I on protein metabolism
https://pmc.ncbi.nlm.nih.gov/articles/PMC1137054 - Insulin-like growth factor-I analogue LR3 IGF-I attenuates loss of lean tissue in rats
https://pubmed.ncbi.nlm.nih.gov/11472075 - Intranasal long R3 insulin-like growth factor-1 treatment promotes amyloid plaque remodeling
https://pubmed.ncbi.nlm.nih.gov/39610283 - IGF-1 LR3 treatment in fetal growth restriction models
https://pubmed.ncbi.nlm.nih.gov/39679943 - Role of IGF1-LR3 in glucose uptake and IGFBP interaction
https://pmc.ncbi.nlm.nih.gov/articles/PMC5750484
Reviews
There are no reviews yet.