1. PRODUCT SUMMARY
SS-31 (Elamipretide) is a cell-permeable, mitochondria-targeting tetrapeptide that selectively associates with cardiolipin in the inner mitochondrial membrane. In experimental research, SS-31 serves as a high-precision tool for investigating mitochondrial bioenergetics and cellular resilience. By stabilizing the mitochondrial cristae and enhancing electron transport chain efficiency, this compound is vital for studies involving oxidative stress modulation and the prevention of mitochondrial dysfunction in various disease models.
2. STORAGE & HANDLING PROTOCOL
Lyophilized State: Store at 2–8°C (36–46°F). Keep desiccated and protected from direct UV light. For extended shelf life, storage at -20°C (-4°F) is advised.
Reconstitution: Use sterile, laboratory-grade diluents such as bacteriostatic water.
Stability: Avoid repetitive freeze-thaw cycles once the solution is prepared. Handle under aseptic conditions to maintain research integrity.
3. PRIMARY RESEARCH AREAS
Mitochondrial Bioenergetics: Investigating oxidative phosphorylation, ATP synthesis rates, and coupling efficiency.
Cardiolipin Dynamics: Modeling the stabilization of the inner mitochondrial membrane and respiratory supercomplex organization.
Redox Signaling: Experiments focusing on the mitigation of reactive oxygen species (ROS) and maintenance of mitochondrial homeostasis.
Stress Resilience Models: Preclinical investigation of mitochondrial protection during ischemia-reperfusion injury and cellular stress.
4. REGULATORY DISCLAIMER
NOTICE: This product is supplied strictly for laboratory research and development. It is STRICTLY NOT FOR HUMAN OR VETERINARY USE, nor is it intended for any clinical, therapeutic, or diagnostic applications. Handling must be performed by qualified scientific professionals in a controlled environment.
5. REFERENCES
- The mitochondrially targeted peptide elamipretide (SS-31) rapidly improves mitochondrial function and binds directly to the ADP transporter ANT
https://pmc.ncbi.nlm.nih.gov/articles/PMC10643647/ - Mitochondrial protein interaction landscape of SS-31
https://pubmed.ncbi.nlm.nih.gov/32554501/ - Elamipretide (SS-31) improves mitochondrial dysfunction and stabilizes mitochondrial cristae structure
https://pmc.ncbi.nlm.nih.gov/articles/PMC8141144/ - SS-31, a mitochondria-targeting peptide, ameliorates mitochondrial fragmentation in fibroblasts from patients with DCMA
https://pmc.ncbi.nlm.nih.gov/articles/PMC6873783/ - Mitochondria-targeting peptide SS-31 attenuates generation of lipid peroxidation and reactive oxygen species
https://pubmed.ncbi.nlm.nih.gov/38521160/ - Elamipretide (SS-31) treatment attenuates age-associated functional deficits in the heart
https://pubmed.ncbi.nlm.nih.gov/34480713/ - Structure-activity relationships of mitochondria-targeted peptides with cardiolipin interactions
https://elifesciences.org/articles/75531
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